The restrictions will affect at least 20 million people across 10 cities, including the capital, Wuhan, where the virus emerged.
On Thursday, a corona virus patient died in northern Hebei province – making it the first death outside Hubei.
Another death was later confirmed in north-east Heilongjiang province.
The province borders Russia and is more than 2,000 kilometers (1,200 miles) from Wuhan.
‘We’ve been advised not to leave our rooms’
Has China learned lessons since deadly SARS epidermic?
Nationally, there are currently 830 confirmed cases of patients infected with the virus.
A small number of confirmed cases have also been found outside China, including in Thailand, the US, Taiwan, South Korea, Japan, Vietnam and Singapore.
The growing list of restrictions comes on the eve of Lunar New Year – one of the most important dates in the Chinese calendar, when millions of people travel home.
Travel restrictions vary from city to city.
Wuhan is effectively on lock down: all bus, subway and ferry services have been suspended and all outbound planes and trains cancelled.
China’s travel industry counts cost of corona virus
Residents have been advised not to leave, and roadblocks have been reported.